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KMID : 1011420230280030249
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Journal of Korean Ophthalmic Optics Society
2023 Volume.28 No. 3 p.249 ~ p.254
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Antioxidant Effects of Parthenocissus tricuspidata Extract for Preventing and Treatment of Age-Related Macular Degeneration
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Ban Ju-Yeon
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Abstract
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Purpose : Antioxidants are frequently involved in the prevention and treatment of eye diseases, including age-related macular degeneration (AMD). Based on several studies, Parthenocissus tricuspidata, a common plant is known for its numerous effects on various diseases such as dry eye disease, diabetes, high blood pressure, and blood circulation.
Methods : To examine the antioxidant effect of P. tricuspidata, we first measured its antioxidant activity. Optimal nontoxic concentrations for cellular activity were determined and the activities of various antioxidant enzymes were evaluated. Additionally, the efficacy of P. tricuspidata was comprehensively evaluated by measuring the concentrations of lipid peroxides (MDA) and reactive oxygen species (ROS).
Results : We observed a statistically significant increase in the antioxidant activity with increasing concentrations of P. tricuspidata extract (10, 50, 100, and 500 μg/mL). Cellular viability assessment at each concentration confirmed no cytotoxicity, along with a concentration-dependent increase in the activity of antioxidant enzymes. Notably, the P. tricuspidata extract significantly reduced MDA concentration and ROS levels induced by hydrogen peroxide, which causes cell death.
Conclusions : This study demonstrated that P. tricuspidata extract possesses antioxidant properties, suggesting its potential use as a functional material for preventing and treating eye diseases, including AMD.
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KEYWORD
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Antioxidant, SH-SY5Y, Parthenocissus tricuspidate, Age-related macular degeneration
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